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Bone marrow microenvironment of patients with systemic lupus erythematosus
T Otsuka1, K Nagasawa, M Harada
1First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
The Journal of Rheumatology
|June 1, 1993
Abstract:
In an attempt to clarify the hematologic abnormality in systemic lupus erythematosus (SLE), we studied the bone marrow microenvironment of 8 women with this disease. The number of fibroblast colonies was similar to that of healthy control individuals. Culture supernatants of monocytes obtained from the patients with SLE showed a diminished production of the hemopoietic growth factor required to stimulate bone marrow fibroblasts. As the activity of the humoral factor released from SLE monocytes was diminished, such a reduction may play a role in the pathogenesis of the hematologic abnormality seen in SLE.