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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Epidemiologic aspects of heart failure: incidence, causes and follow-up]
1Kardiologische Abteilung, Medizinische Klinik, Stadtspital Triemli, Zürich.
Insights
Congestive heart failure (CHF) is a growing complication of heart disease, particularly in older adults. Early diagnosis and management are crucial for improving patient outcomes and reducing mortality rates.
Area of Science:
- Cardiology
- Public Health
Context:
- Congestive heart failure (CHF) is a significant complication across all heart disease types, with prevalence increasing markedly with age.
- CHF is a leading cause of hospital admissions in adult internal medicine, highlighting its public health burden.
Purpose:
- To summarize the epidemiology, etiology, and prognosis of congestive heart failure (CHF).
- To provide an overview of the factors contributing to CHF decompensation and mortality.
Summary:
- CHF prevalence varies by diagnostic criteria but rises with age, affecting 1% in the US and 0.4% in Great Britain.
- Coronary artery disease and hypertensive heart disease are leading causes of CHF, while cardiomyopathies affect younger patients. Acute ischemic events and compliance issues trigger decompensation.
- CHF progression is linked to increased mortality, with 30-50% of patients experiencing sudden death.
Impact:
- Understanding CHF's epidemiology and risk factors can inform public health strategies and clinical practice.
- This overview aids healthcare professionals in managing CHF patients, addressing decompensation, and improving long-term prognosis.
Abstract:
Congestive heart failure can develop as a complication of virtually all forms of heart diseases. Depending on diagnostic criteria, the figures for prevalence and incidence differ markedly. The frequency of congestive heart failure increases with age and doubles in each life decade. In the United States the prevalence of 1% and for Great Britain 0.4% respectively have been calculated. In the highest age groups up to 90 new cases/1000 population per year can be observed. As a contribution to decreasing mortality of acute myocardial infarction and better treatment of high blood pressure as well as congestive heart failure the number of patients in heart failure have increased substantially. In contrast to the Framingham Study, nowadays coronary artery disease is the most prevalent etiology of congestive heart failure followed by hypertensive heart disease. In younger patient groups with advanced heart failure, like heart transplant recipients, cardiomyopathies are the main etiologic factor. Heart failure is the leading factor for emergency admissions to hospital in adult internal medicine. The main reasons for decompensation are acute ischemic syndromes for acute congestive heart failure and compliance problems for chronic congestive heart failure. The natural history of congestive heart failure is characterized by a marked progression, increasing with the severity of heart failure. In parallel, mortality increases, too. A variety of clinical, hemodynamic neurohumoral and electrophysiologic factors have been described as independent factors predicting prognosis. 30 to 50% of heart failure patients die a sudden death as compared with progressive pump failure or infectious complications in the others.
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