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Normal values for random urinary calcium to creatinine ratios in infancy
J D Sargent1, T A Stukel, J Kresel
1Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
The Journal of Pediatrics
|September 1, 1993
Summary
Normal urinary calcium/creatinine ratio (UCa/Cr) is significantly higher in infants compared to older children and adults. Short-term infant formula supplementation with calcium and phosphorus showed minimal impact on infant UCa/Cr levels.
Area of Science:
- Pediatric Nephrology
- Clinical Chemistry
- Nutritional Science
Background:
- The urinary calcium/creatinine ratio (UCa/Cr) is a key indicator of calcium homeostasis.
- Establishing age-specific normal ranges for UCa/Cr is crucial for accurate clinical assessment in infants.
Purpose of the Study:
- To determine reference values for UCa/Cr in infants.
- To evaluate the effect of calcium and phosphorus supplementation in infant formula on UCa/Cr.
Main Methods:
- UCa/Cr was measured in urine samples from infants, children, and adults.
- A before-and-after trial assessed UCa/Cr changes during short-term infant formula supplementation with calcium glycerophosphate.
Main Results:
- UCa/Cr significantly decreases with age, with the highest values observed in infants (<7 months).
- Infant UCa/Cr geometric means were significantly higher than in older children and adults.
- Formula supplementation did not significantly alter mean UCa/Cr in infants.
Conclusions:
- Normal UCa/Cr values are substantially higher in infants than in older age groups.
- UCa/Cr demonstrates an age-related decline during early childhood.
- Calcium and phosphorus supplementation of infant formula has a negligible short-term effect on infant UCa/Cr.