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Histopathologic changes in the temporal bone resulting from measles infection

J E Bordley, Y P Kapur

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |March 1, 1977
    PubMed

    Insights

    Acute measles infection caused severe necrotizing otitis media in children. Pathologic changes included Warthin-Finkelday giant cells and inner ear damage, resembling rubella effects.

    Area of Science:

    • Pathology
    • Otolaryngology
    • Pediatrics

    Background:

    • Measles infection can lead to severe complications.
    • Otitis media is a common complication in children.
    • Temporal bone pathology provides insight into disease mechanisms.

    Observation:

    • Four children with fatal measles-induced bronchopneumonia were examined.
    • All cases exhibited severe necrotizing otitis media with round cell infiltration.
    • Multilobulated giant cells (Warthin-Finkelday) were identified in one middle ear.

    Findings:

    • Inner ear changes were observed in two cases.
    • One case showed significant nerve fiber and ganglion cell loss with striae vascularis atrophy.
    • Adhesions in the cochlear duct resembled those seen in congenital rubella.

    Implications:

    • Measles can cause significant temporal bone pathology, including otitis media and inner ear damage.
    • The presence of Warthin-Finkelday cells highlights a potential link between systemic measles and middle ear pathology.
    • Findings suggest a possible overlap in the otologic manifestations of measles and congenital rubella.

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