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Histopathologic changes in the temporal bone resulting from measles infection
Archives of Otolaryngology (Chicago, Ill. : 1960)
|March 1, 1977
Summary
Acute measles infection caused severe necrotizing otitis media in children. Pathologic changes included Warthin-Finkelday giant cells and inner ear damage, resembling rubella effects.
Area of Science:
- Pathology
- Otolaryngology
- Pediatrics
Background:
- Measles infection can lead to severe complications.
- Otitis media is a common complication in children.
- Temporal bone pathology provides insight into disease mechanisms.
Observation:
- Four children with fatal measles-induced bronchopneumonia were examined.
- All cases exhibited severe necrotizing otitis media with round cell infiltration.
- Multilobulated giant cells (Warthin-Finkelday) were identified in one middle ear.
Findings:
- Inner ear changes were observed in two cases.
- One case showed significant nerve fiber and ganglion cell loss with striae vascularis atrophy.
- Adhesions in the cochlear duct resembled those seen in congenital rubella.
Implications:
- Measles can cause significant temporal bone pathology, including otitis media and inner ear damage.
- The presence of Warthin-Finkelday cells highlights a potential link between systemic measles and middle ear pathology.
- Findings suggest a possible overlap in the otologic manifestations of measles and congenital rubella.