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Bacteremia in children with acute lymphoblastic leukemia
Zhonghua Minguo Xiao Er Ke Yi Xue Hui Za Zhi [Journal]. Zhonghua Minguo Xiao Er Ke Yi Xue Hui
|May 1, 1993
Summary
Bacteremia in children with acute lymphoblastic leukemia (ALL) is a serious complication. Prompt antibiotic treatment and supportive care significantly improve outcomes for these young patients.
Area of Science:
- Pediatric Oncology
- Infectious Diseases
- Hematology
Background:
- Bacteremia is a significant complication in treating hematological malignancies.
- Children undergoing treatment for acute lymphoblastic leukemia (ALL) are particularly vulnerable.
Purpose of the Study:
- To analyze the incidence, pathogens, and outcomes of bacteremia in pediatric ALL patients.
- To identify factors associated with poor outcomes in bacteremic episodes.
Main Methods:
- Retrospective analysis of 72 children with ALL treated between July 1988 and October 1991.
- Review of blood cultures, patient records, and clinical outcomes.
Main Results:
- 26% of patients had positive blood cultures, with 24 bacteremic episodes.
- Gram-negative bacteria (62.5%) were the most common pathogens, including E. coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
- 83% of episodes occurred during neutropenia; Pseudomonas etiology, pneumonia, and shock were linked to poor outcomes, with an overall mortality of 26.3%.
Conclusions:
- Intensive supportive care and effective antibiotics are crucial for improving bacteremia outcomes in pediatric ALL.
- Improved management of bacteremia contributes to the overall success of recent ALL treatments.