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Comparative effects of gold on the interactions of transcription factors with DNA
M L Handel1, S Sivertsen, C K Watts
1Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia.
Agents and Actions. Supplements
|January 1, 1993
Abstract:
We have previously hypothesized that a mode of action of the anti-rheumatic gold salt, aurothiomalate (AuTM), is the inhibition of DNA binding by transcription factors. Studies of the progesterone receptor (PR), which has a zinc finger structure in the DNA binding domain, were consistent with this hypothesis (1). Here we show that AuTM also markedly inhibits DNA binding by the transcription factor AP-1 and has less potent effects for AP-2, NF-1 and TFIID.