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[Solid phase techniques in blood group serology]

H Uthemann1, L Sturmfels, V Lenhard

  • 1BIOTEST AG, Dreieich, BRD.

Infusionstherapie Und Transfusionsmedizin
|June 1, 1993
PubMed
Summary
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Solid-phase red blood cell adherence assays in microplates offer advantages over hemagglutination. These automated methods improve blood group typing, Rh phenotyping, and antibody screening for better transfusion safety.

Area of Science:

  • Immunology
  • Hematology
  • Clinical Pathology

Context:

  • Hemagglutination assays are traditional methods for blood typing and antibody screening.
  • Solid-phase red blood cell adherence assays offer enhanced sensitivity and automation potential.
  • Microplate adaptation of these assays facilitates high-throughput processing and objective data analysis.

Purpose:

  • To describe the adaptation and application of solid-phase red blood cell adherence assays in microplates.
  • To detail the use of these assays for ABO grouping, Rh typing, Rh phenotyping, antibody screening and identification, and crossmatching.
  • To highlight the advantages of microplate-based assays over conventional hemagglutination techniques.

Summary:

  • Solid-phase red blood cell adherence assays utilizing microplates are presented as superior alternatives to hemagglutination.

Related Experiment Videos

  • These assays enable semi-automated processing, spectrophotometric reading, and computer-based interpretation.
  • The paper outlines the application of these advanced techniques across various blood group serology tests, including typing, phenotyping, antibody analysis, and crossmatching.

    • Impact:

    • Facilitates more efficient and accurate blood group serology testing.
    • Enhances transfusion safety through improved antibody screening and crossmatching.
    • Promotes the adoption of automated, microplate-based diagnostic platforms in clinical laboratories.