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Skeletal growth after oral administration of demineralized bone matrix
J A Martínez1, M Elorriaga, M Marquínez
1Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain.
Revista Espanola De Fisiologia
|March 1, 1993
Abstract:
Oral administration of bone extracts obtained from bovine demineralized bone matrix to rats has a direct effect on bone metabolism, affecting bone proportions and some markers of bone formation such as bone malate dehydrogenase, serum alkaline phosphatase and serum osteocalcin. Furthermore collagen deposition, bone protein synthesis and nucleic acids content were significantly increased by the treatment.