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Autonomic dysfunction in peripheral nerve disease

J G McLeod1

  • 1Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, N.S.W., Australia.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|January 1, 1993
PubMed
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Autonomic dysfunction, often linked to peripheral neuropathies, can cause serious issues like orthostatic hypotension. Early identification and management of underlying causes are key for patients with autonomic neuropathy.

Area of Science:

  • Neurology
  • Autonomic Nervous System Disorders
  • Peripheral Neuropathy

Background:

  • Autonomic dysfunction is a frequent complication of peripheral neuropathies.
  • While often minor, it can manifest as significant disturbances in autonomic function.
  • Conditions affecting small nerve fibers or causing demyelination are prone to causing autonomic dysfunction.

Purpose of the Study:

  • To review the clinical significance and management of autonomic dysfunction in peripheral neuropathies.
  • To identify specific conditions associated with severe autonomic dysfunction.
  • To outline the primary therapeutic strategies for autonomic neuropathy.

Main Methods:

  • Literature review of peripheral neuropathies and autonomic dysfunction.
  • Analysis of conditions causing acute and chronic autonomic disturbances.

Related Experiment Videos

  • Synthesis of management approaches for autonomic neuropathy.

    • Main Results:

    • Autonomic dysfunction severity varies, with some cases causing orthostatic hypotension, heart rate, bladder, and erectile dysfunction.
    • Acute onset neuropathies and those affecting small fibers are more likely to cause significant autonomic issues.
    • Severe autonomic dysfunction is associated with conditions including diabetes, Guillain-Barré syndrome, and amyloidosis.

    Conclusions:

    • Autonomic dysfunction is a critical aspect of certain peripheral neuropathies requiring attention.
    • Effective management involves addressing the root cause and providing symptomatic relief.
    • Understanding the link between nerve fiber pathology and autonomic symptoms is crucial for diagnosis and treatment.