[Superoxide-removing activity of gastric juice in gastroduodenal diseases]

A decrease in the superoxide anion-obviating activity of gastric juice was detected in patients with chronic gastroduodenitis and duodenal ulcerous disease, whose rate depended on the disease stage, functional state of the stomach and nature of the disease course. Deficiency in H+, Cu2+ and a decrease of glutathione content in gastric juice were found to be responsible for the phenomenon observed. The superoxide anion-obviating activity of gastric juice exhibited the regulatory effect on resistance of the duodenal mucosal membrane, which is prerequisite to restoration of the pattern studied during medicinal treatment. Antacid biphilact produced from sour milk was used for the treatment of the disease.