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Development of alpha beta T cells

A M Kruisbeek1

  • 1Division of Immunology, The Netherlands Cancer Institute, Amsterdam.

Current Opinion in Immunology
|April 1, 1993
PubMed

Developing T cells in the thymus are subject to a screening process, through interactions with thymic stromal cells, from which T cells with appropriate T-cell receptors are selected. The recent generation of T-cell receptor transgenic mice and mice homozygous for disrupted T-cell receptor genes have now supplied tools that improve the prospect for a better understanding of the molecular mechanisms of this thymic selection process. In addition these model systems appear to indicate a role for a, not yet fully characterized, pre-T cell receptor complex in survival and further differentiation of pre-T cells.

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