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Prostaglandin E2 increased rat cortical bone mass when administered immediately following ovariectomy
1Division of Radiobiology, University of Utah School of Medicine, Salt Lake City 84112.
Bone and Mineral
|June 1, 1993
Summary
Ovariectomy in rats stimulates bone resorption and marrow expansion. Prostaglandin E2 (PGE2) administration prevents these ovariectomy-induced changes, increasing bone mass in the tibial shaft.
Area of Science:
- Bone Biology
- Endocrinology
- Pharmacology
Background:
- Ovariectomy (OVX) is a common model for postmenopausal bone loss.
- The effects of prostaglandin E2 (PGE2) on bone remodeling after OVX require further investigation.
Purpose of the Study:
- To investigate the impact of PGE2 on tibial shaft cortical bone histomorphometry in OVX rats.
- To determine if PGE2 can mitigate OVX-induced bone changes.
Main Methods:
- Thirty-five female Sprague-Dawley rats underwent OVX or sham-OVX.
- OVX rats received varying doses of PGE2 (0, 1, or 6 mg/kg/day) for 90 days.
- Histomorphometry analysis was performed on undecalcified tibial shaft cross-sections.
Main Results:
- OVX increased marrow area and endocortical bone resorption.
- Low-dose PGE2 (1 mg/kg/day) prevented OVX-induced increases in marrow area and resorption, adding bone.
- High-dose PGE2 (6 mg/kg/day) increased total bone area and periosteal bone formation but also intracortical porosity.
Conclusions:
- OVX stimulates endocortical bone resorption and marrow expansion in rat tibial shafts.
- PGE2 effectively prevents OVX-induced bone resorption and marrow expansion.
- PGE2 administration can increase total bone mass in OVX rats, suggesting therapeutic potential.