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A method for stabilising technetium-99m exametazime prepared from a commercial kit
P S Weisner1, G R Bower, L A Dollimore
1Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, UK.
European Journal of Nuclear Medicine
|August 1, 1993
Summary
Technetium-99m exametazime (99mTc-d,l-HMPAO) brain imaging kits have a short 30-minute shelf life. Adding cobalt chloride hexahydrate extends this stability to 5 hours, improving clinical availability.
Area of Science:
- Radiopharmacy
- Nuclear Medicine
- Medical Imaging
Background:
- Technetium-99m exametazime (99mTc-d,l-HMPAO) is crucial for assessing regional cerebral blood flow.
- The Ceretec kit formulation has a limited 30-minute stability post-reconstitution, restricting its clinical use.
Purpose of the Study:
- To evaluate methods for extending the shelf life of reconstituted 99mTc-d,l-HMPAO kits.
- To introduce a stabilization method to enhance clinical availability.
Main Methods:
- Investigated various approaches to prolong the stability of 99mTc-d,l-HMPAO.
- Described a specific method involving the addition of cobalt chloride hexahydrate (CoCl2 x 6H2O) to the reconstituted kit.
Main Results:
- The addition of 200 micrograms of cobalt chloride hexahydrate in 2 ml of water stabilized the kit.
- Extended the radiochemical purity of the lipophilic complex to at least 5 hours post-reconstitution.
Conclusions:
- Cobalt chloride hexahydrate effectively extends the shelf life of 99mTc-d,l-HMPAO kits.
- This stabilization method significantly improves the clinical availability of this diagnostic agent.