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Cloning and characterization of human TNF alpha promoter region
S Takashiba1, L Shapira, S Amar
1Department of Periodontology, Eastman Dental Center, Rochester, NY 14620.
Gene
|September 15, 1993
Abstract:
We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNF alpha) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.