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Related Experiment Videos

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) decrease in diastolic left

Y Suzuki1, K Harada, Y Miura

  • 1Department of Pediatrics, Akita University School of Medicine, Japan.

Pediatric Cardiology
|July 1, 1993
PubMed
Summary
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Patients with MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) exhibit thickened heart walls and impaired diastolic function, indicating cardiomyopathy. Systolic function remains unaffected.

Area of Science:

  • Cardiology
  • Neurology
  • Genetics

Background:

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a multisystem disorder.
  • Cardiomyopathy is a known complication of MELAS syndrome.

Purpose of the Study:

  • To investigate left ventricular systolic and diastolic functions in patients with MELAS.
  • To compare cardiac function in MELAS patients with healthy controls.

Main Methods:

  • Utilized M-mode and Doppler echocardiography to assess cardiac function.
  • Evaluated interventricular septal thickness, left ventricular posterior wall thickness, and mitral valve flow velocity.
  • Compared parameters between four MELAS patients and 14 normal controls.

Main Results:

Related Experiment Videos

  • MELAS patients showed significantly increased interventricular septal and posterior wall thickness compared to controls.
  • No significant differences were observed in systolic left ventricular function parameters or dimensions.
  • Doppler echocardiography revealed impaired diastolic left ventricular filling in MELAS patients, evidenced by decreased early passive filling velocity (E) and related indexes.

Conclusions:

  • Patients with MELAS exhibit cardiac structural changes (hypertrophy) and diastolic dysfunction.
  • Systolic left ventricular function is preserved in MELAS patients.
  • Diastolic dysfunction may be a significant feature of cardiomyopathy in MELAS syndrome.