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Heparin in experimental hyperdynamic sepsis

J Meyer1, C S Cox, D N Herndon

  • 1Department of Anesthesiology, University of Texas Medical Branch, Galveston 77555-1091.

Critical Care Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Heparin administration in experimental sepsis improved cardiac output and preserved gas exchange in sheep. However, it lowered systemic vascular resistance and mean arterial pressure during the hyperdynamic state.

Area of Science:

  • Cardiovascular Physiology
  • Sepsis Pathophysiology
  • Pharmacological Interventions

Background:

  • Sepsis-induced hyperdynamic circulatory dysfunction presents significant challenges.
  • Understanding the role of anticoagulants like heparin in sepsis is crucial for therapeutic strategies.

Purpose of the Study:

  • To investigate the effects of heparin on cardiac output and oxygenation during experimental hyperdynamic sepsis in a sheep model.
  • To evaluate heparin's influence on cardiopulmonary performance in sepsis.

Main Methods:

  • A prospective trial involving 14 sheep subjected to continuous Escherichia coli endotoxin infusion.
  • Administration of heparin (5000 units intravenously every 4 hrs) to seven sheep, with seven serving as controls.
  • Monitoring of cardiovascular parameters (cardiac index, systemic vascular resistance index, mean arterial pressure) and gas exchange.

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Main Results:

  • Heparinized sheep exhibited an initial increase in cardiac index and decrease in systemic vascular resistance index.
  • A hyperdynamic state with increased cardiac index and decreased systemic vascular resistance index was observed in heparinized animals.
  • Heparin preserved gas exchange in the early and mid-phases, while controls showed deterioration later in endotoxemia.

Conclusions:

  • Heparin significantly modulated cardiopulmonary performance in experimental hyperdynamic sepsis.
  • Heparin administration improved cardiac output and maintained gas exchange.
  • Heparin lowered systemic vascular resistance and mean arterial pressure in the hyperdynamic phase of sepsis.