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Updated: Aug 10, 2026
11:10
Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
[Deficiency of mannan-binding protein--a recently discovered complement defect syndrome]
P Garred1, S Thiel, H O Madsen
1Vaevstypelaboratoriet, Rigshospitalet, København.
Ugeskrift for Laeger
|January 4, 1993
Summary
Mannan-binding protein (MBP) deficiency increases infection risk in infants. This serum protein is crucial for the complement system and may help diagnose childhood immunodeficiencies.
Area of Science:
- Immunology
- Biochemistry
Context:
- Mannan-binding protein (MBP) is a recently identified serum protein.
- It plays a role in the innate immune system by activating the complement cascade.
- MBP deficiency is linked to increased susceptibility to infections, particularly in infancy.
Purpose:
- To discuss the structure and physiological functions of Mannan-binding protein (MBP).
- To highlight the role of MBP in the classical complement pathway.
- To explore the potential of MBP as a diagnostic marker for pediatric immunodeficiencies.
Summary:
- MBP, a C-type lectin with a collagen-like structure, binds to mannose-rich microbial surfaces, initiating complement activation via the classical pathway.
- Deficiency in MBP is associated with recurrent infections during infancy.
- The structural and functional aspects of MBP are detailed, emphasizing its immunological significance.
Impact:
- MBP's role in complement activation provides insights into host defense mechanisms against pathogens.
- Understanding MBP deficiency can lead to improved diagnosis and management of primary immunodeficiencies in children.
- This research underscores the importance of MBP in pediatric immunology and infectious disease.
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