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Granulocyte function in bacterial infections in man

K B Hellum, C O Solberg

    Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
    |February 1, 1977
    PubMed
    Summary
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    Bacterial infections can impair neutrophil granulocyte function, reducing their ability to fight bacteria. This dysfunction, indicated by nitroblue tetrazolium (NBT) dye reduction and morphology, may contribute to fatal outcomes in patients.

    Area of Science:

    • Immunology
    • Hematology
    • Infectious Diseases

    Background:

    • Neutrophil granulocytes play a critical role in combating bacterial infections.
    • Assessing neutrophil function is crucial for understanding infection severity and patient outcomes.

    Purpose of the Study:

    • To examine nitroblue tetrazolium (NBT) dye reduction and phagocytic/bactericidal activities of neutrophils in bacterial infection patients.
    • To correlate these functional assessments with granulocyte morphology and clinical outcomes.

    Main Methods:

    • Evaluated NBT dye reduction capacity in neutrophils from 141 bacterial infection patients and 141 controls.
    • Assessed phagocytic and bactericidal activities of neutrophils.
    • Correlated functional data with neutrophil morphology (vacuolization, toxic granulation) and patient survival.

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    Main Results:

    • 82% of patients showed higher NBT reduction capacity than controls; this correlated with morphological changes.
    • 35% of patients had reduced neutrophil bactericidal activity, often associated with increased juvenile neutrophils.
    • Impaired bactericidal activity was linked to higher mortality, with 12 of 18 deaths occurring in this group.

    Conclusions:

    • Bacterial infections can lead to defects in neutrophil granulocyte function.
    • Impaired neutrophil function, particularly reduced bactericidal activity, may contribute to a fatal outcome in bacterial infections.
    • NBT reduction capacity and neutrophil morphology provide insights into granulocyte dysfunction during infection.