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Fast perfluorocarbon imaging using 19F U-FLARE

P Börnert1, D G Norris, H Koch

  • 1Universität Bremen, FRG.

Magnetic Resonance in Medicine
|February 1, 1993
PubMed
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This study introduces an ultra-fast 19F imaging technique for perfluorocarbons (PFCs), enabling rapid in vivo measurement of biodistribution, oxygen tension, and diffusion. The method offers high signal-to-noise for advanced PFC imaging applications.

Area of Science:

  • Magnetic Resonance Imaging
  • Fluorine-19 (19F) Spectroscopy
  • Biomedical Engineering

Background:

  • Perfluorocarbons (PFCs) are investigated as temporary blood substitutes.
  • Accurate in vivo monitoring of PFC biodistribution and physiological parameters is crucial.
  • Existing imaging techniques may lack the speed and sensitivity for dynamic PFC studies.

Purpose of the Study:

  • To describe an ultra-fast low angle RARE 19F imaging technique for PFCs.
  • To extend the technique for measuring fluorine T1 values and oxygen tension.
  • To present 19F diffusion measurements of PFCs.

Main Methods:

  • Application of an ultra-fast low angle RARE sequence for 19F imaging.
  • Chemical shift selective measurement of fluorine T1 values.

Related Experiment Videos

  • Diffusion-sensitized 19F imaging sequence.

    • Main Results:

    • Demonstration of high signal-to-noise ratio for fast in vivo PFC biodistribution studies.
    • Successful in vivo measurement of oxygen tension using the T1 relaxation rate of PFCs.
    • Presentation of 19F diffusion constant measurements for PFCs.

    Conclusions:

    • The developed ultra-fast 19F RARE technique is suitable for rapid in vivo PFC imaging.
    • The method enables simultaneous assessment of PFC biodistribution, oxygen tension, and diffusion.
    • This imaging approach holds promise for evaluating PFC-based blood substitutes.