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Updated: Aug 11, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Pseudohyponatremia in multiple myeloma
1Department of Internal Medicine, St. Louis University School of Medicine, Mo.
Abstract:
Severe hyponatremia in any asymptomatic patient should alert the clinician to the possibility that pseudohyponatremia may be attendant with chylomicronemia or paraproteinemia. In cases of chylomicronemia, the serum is creamy, and in paraproteinemia the serum has increased viscosity. In such cases, the calculated serum osmolality will be decreased but the measured value will be within the normal range. Hyponatremia in an asymptomatic patient demands careful evaluation before institution of therapy. In addition, the presence of a normal serum sodium level in a patient with multiple myeloma should alert the clinician to the possibility that hypernatremia and hypertonicity may be present.
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