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Published on: April 25, 2025
Suspected nafcillin-induced interstitial nephritis
S R Guharoy1, S Kar, J McGalliard
1John F. Kennedy Memorial Hospital, Indio, CA 92201.
Objective:
To present a case of nafcillin-induced interstitial nephritis.
Methodology:
Case report and literature review.
Setting:
Hospital.
Results:
Three days following initiation of nafcillin therapy for staphylococcal pneumonia, an 80-year-old woman developed allergic manifestations and progressive renal impairment suggestive of acute allergic interstitial nephritis. These manifestations were completely reversed within 96 hours of cessation of nafcillin therapy.
Conclusions:
In the clinical setting of acute renal failure in a patient on nafcillin therapy, acute interstitial nephritis should be considered. Prompt cessation of nafcillin therapy has generally been associated with reversal of symptoms and an improvement in renal function.
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