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Hypercoagulable states

J S Rogers1

  • 1Section of Endocrinology and Metabolism, West Virginia University Health Sciences Center.

The West Virginia Medical Journal
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Hypercoagulable states increase the risk of blood clots (thrombi). Evaluating for inherited defects in natural anticoagulation systems is crucial for individuals with unexplained thrombosis.

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Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Hypercoagulable states signify an increased tendency for thrombus formation in veins or arteries.
  • Virchow's triad (blood alterations, vascular injury, stasis) remains foundational to understanding thrombosis.
  • Advances in molecular biology have identified inherited defects in natural anticoagulation pathways.

Purpose of the Study:

  • To review primary and secondary hypercoagulable states.
  • To highlight inherited defects in anticoagulation systems.
  • To discuss the clinical evaluation and management of hypercoagulable conditions.

Main Methods:

  • Literature review of thrombosis and hypercoagulability.
  • Analysis of inherited defects in antithrombin III, protein C, protein S, and fibrinogen.

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  • Discussion of clinical indicators for primary hypercoagulable defects.

    • Main Results:

    • Primary hypercoagulable states include deficiencies in antithrombin III, protein C, protein S, dysfibrinogenemias, and plasminogen-related abnormalities.
    • Clinical presentation of primary defects often involves early-onset, familial, recurrent, or unusually located thrombosis.
    • Secondary hypercoagulable states are associated with various underlying conditions, often with multifactorial etiologies.

    Conclusions:

    • Identifying specific inherited defects is vital for patients with suggestive clinical histories.
    • While specific defects are found in a minority, secondary hypercoagulable states are common.
    • Managing underlying conditions may mitigate the risk of thrombosis in secondary hypercoagulable states.