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Oral candidiasis established in the sialoadenectomised rat
A O Jorge1, M A Totti, O P de Almeida
1Department of Oral Pathology, Faculty of Dentistry, Piracicaba-SP, Brasil.
Summary
Surgical removal of major salivary glands in rats led to xerostomia (dry mouth), increasing oral candidiasis development. Candidiasis affected 70% of xerostomic rats, including the pharyngeal tongue, unlike normal rats.
Area of Science:
- Oral biology
- Microbiology
- Immunology
Background:
- Xerostomia, or dry mouth, is a condition that can increase the risk of oral infections.
- Salivary glands play a crucial role in maintaining oral health and preventing microbial overgrowth.
Purpose of the Study:
- To investigate the impact of surgically induced xerostomia on the development of oral candidiasis in a rat model.
- To determine the prevalence and location of Candida infection in xerostomic versus normal rats.
Main Methods:
- Surgical removal of major salivary glands in rats to induce xerostomia.
- Inoculation with Candida species.
- Monitoring and assessment of oral candidiasis development over 32 weeks.
Main Results:
- Xerostomic rats exhibited a significantly higher incidence of oral candidiasis (70%) compared to normal rats (20%) after 32 weeks.
- Candida infection in xerostomic rats extended to the pharyngeal aspect of the tongue, a site not affected in normal rats.
Conclusions:
- Surgically induced xerostomia promotes the development and spread of oral candidiasis.
- Salivary gland function is critical for controlling Candida colonization in the oral cavity, including the pharyngeal region.