Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Desmosomes and hemidesmosomes

D R Garrod1

  • 1Department of Cell and Structural Biology, University of Manchester, UK.

Current Opinion in Cell Biology
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Desmosomes and hemidesmosomes differ significantly in molecular makeup, with specialized proteins for plaque formation and filament attachment. Their glycoproteins exhibit diverse expression, suggesting roles in cell signaling and tissue-specific functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative enzymology of native and recombinant house dust mite allergen Der p 1.

Allergy·2009
Same author

Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases.

Allergy·2007
Same author

Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.

European journal of cancer (Oxford, England : 1990)·2004
Same author

The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus.

The British journal of dermatology·2004
Same author

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix.

Virchows Archiv : an international journal of pathology·2003
Same author

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning.

Nature cell biology·2001
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Area of Science:

  • Cell biology
  • Molecular biology
  • Biochemistry

Background:

  • Desmosomes and hemidesmosomes are crucial cell-cell and cell-matrix adhesion structures.
  • Their molecular composition and functional roles are areas of active research.

Purpose of the Study:

  • To elucidate the molecular differences between desmosomes and hemidesmosomes.
  • To investigate the heterogeneity and expression patterns of desmosomal glycoproteins.
  • To explore the potential involvement of these junctions in signal transduction.

Main Methods:

  • Comparative analysis of protein and glycoprotein components.
  • Examination of gene families encoding junctional proteins.
  • Study of isoform expression in different tissues and differentiation states.

Related Experiment Videos

Main Results:

  • Desmosomes and hemidesmosomes exhibit distinct molecular compositions.
  • Most protein and glycoprotein components originate from multigene families but are specialized.
  • Desmosomal glycoproteins show greater heterogeneity and varied tissue-specific/differentiation-related expression than previously known.
  • Both junction types can be modulated by extracellular signals.

Conclusions:

  • Desmosomes and hemidesmosomes possess specialized molecular machinery for their respective functions.
  • The heterogeneity of desmosomal glycoproteins suggests complex regulatory mechanisms.
  • These cell junctions may play a significant role in cellular signal transduction pathways.