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Fecal short-chain fatty acid concentrations and effect on ileal pouch function
W L Ambroze1, J H Pemberton, S F Phillips
1Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
Diseases of the Colon and Rectum
|March 1, 1993
Summary
Short-chain fatty acids (SCFAs) are present in ileal pouch effluent after surgery. Fecal SCFA concentration correlates with stool frequency in patients with ileal pouch-anal anastomosis (IPAA).
Area of Science:
- Gastroenterology
- Surgical Outcomes
- Microbiome Research
Background:
- Ileal pouch-anal anastomosis (IPAA) is a surgical procedure for ulcerative colitis.
- Short-chain fatty acids (SCFAs) play crucial roles in intestinal health.
- The impact of SCFAs on pouch function post-IPAA is not fully understood.
Purpose of the Study:
- To investigate SCFA concentrations in IPAA patients.
- To determine the relationship between SCFA levels and stool frequency.
- To assess the pouch's contractile response to SCFAs.
Main Methods:
- Collected stool samples from 14 IPAA patients.
- Quantified individual SCFAs using gas liquid chromatography.
- Assessed pouch contractions manometrically after SCFA or saline infusion.
Main Results:
- Total SCFA concentrations in IPAA patients were comparable to controls.
- A significant inverse relationship was observed between stool frequency and total SCFA concentration (r = 0.73; P < 0.001).
- SCFA infusion did not alter pouch contractile frequency, amplitude, or duration compared to saline.
Conclusions:
- SCFAs are present in ileal pouch effluent.
- Stool frequency in IPAA patients may be influenced by fecal SCFA concentration.
- The ileal pouch does not exhibit the normal contractile response to SCFAs seen in the terminal ileum.