Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinically nonfunctioning pituitary adenomas

P J Snyder1

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.

Endocrinology and Metabolism Clinics of North America
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Amplifying Efficiency and Accuracy in Dementia Drug Development.

The journal of prevention of Alzheimer's disease·2024
Same author

Effect of testosterone treatment on the trabecular bone score in older men with low serum testosterone.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research.

The journal of prevention of Alzheimer's disease·2018
Same author

A Survey of Knowledge and Views Concerning Genetic and Amyloid PET Status Disclosure.

Alzheimer's & dementia (New York, N. Y.)·2016
Same author

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease.

Molecular psychiatry·2014
Same author

Karhunen-Loève treatment to remove noise and facilitate data analysis in sensing, spectroscopy and other applications.

The Analyst·2014
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Clinically nonfunctioning pituitary adenomas often present with neurological symptoms due to size. Diagnosis involves hormone level measurements and in vitro analysis, with surgery as the primary treatment.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Clinically nonfunctioning pituitary adenomas lack distinct hormonal syndromes.
  • These tumors are often diagnosed late due to mass effect, causing neurological symptoms like visual impairment.
  • Gonadotroph and thyrotroph adenomas are more frequently nonfunctioning compared to other types.

Purpose of the Study:

  • To outline the diagnostic challenges and methods for identifying clinically nonfunctioning pituitary adenomas.
  • To detail the primary and adjunctive treatment strategies for these tumors.

Main Methods:

  • In vivo diagnosis through measurement of basal and TRH-stimulated hormone levels (FSH, LH, TSH) and their subunits.
  • In vitro identification via cell culture, immunohistochemistry, and mRNA analysis.

Related Experiment Videos

  • Clinical assessment for neurological deficits, particularly visual disturbances.

    • Main Results:

    • Nonfunctioning adenomas are typically identified by mass effects rather than hormonal overproduction.
    • Diagnostic methods include both in vivo endocrine testing and in vitro molecular/cellular assays.
    • Transsphenoidal surgery is the main therapeutic approach, often supplemented by radiation or medication.

    Conclusions:

    • Early clinical recognition of nonfunctioning pituitary adenomas is challenging.
    • A combination of hormonal assays, imaging, and in vitro studies aids diagnosis.
    • Multimodal treatment, including surgery and potentially radiation or pharmacotherapy, is crucial for management.