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Urinary bladder serosal chemoreceptor induced cardio-respiratory responses: possible pathway
N Shankar1, N Bhattacharya, K N Sharma
1Department of Physiology, University College of Medical Sciences, Shahdara, Delhi.
Indian Journal of Physiology and Pharmacology
|January 1, 1993
Summary
Chemicals applied to the outer bladder surface triggered pain responses in dogs, including increased heart rate and blood pressure. These responses were blocked by numbing agents and nerve قطع, highlighting the sympathetic nervous system
Area of Science:
- Urology
- Neuroscience
- Physiology
Background:
- Limited experimental data exists on urinary bladder pain.
- Understanding bladder pain mechanisms is crucial for clinical management.
Purpose of the Study:
- To investigate the physiological responses to chemical stimulation of the urinary bladder serosa.
- To elucidate the neural pathways involved in bladder-evoked nociception.
Main Methods:
- Chemicals (e.g., ammonium oxalate, bradykinin) were applied to the serosal surface of anesthetized dog bladders.
- Cardio-respiratory and bladder wall responses were monitored.
- Nerve sections (hypogastric, vagus, pelvic) and spinalectomy were performed.
- Pharmacological agents (procaine, tolazoline) were administered.
Main Results:
- Serosal chemical application induced significant cardio-respiratory facilitation and bladder contractions.
- Mucosal application did not elicit notable responses.
- Responses were abolished by procaine, hypogastric nerve section, and T8 spinalectomy.
- Tolazoline administration abolished blood pressure responses, indicating sympathetic involvement.
Conclusions:
- The study demonstrates a specific nociceptive reflex originating from the urinary bladder serosa.
- The sympathetic nervous system plays a significant role in mediating bladder pain responses.
- These findings provide insights into the neurophysiological basis of bladder pain.