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Synthesis and pharmacological activity of imidazo[2,1-b]benzothiazole acids
G Grandolini1, V Ambrogi, L Perioli
1Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Facoltà di Farmacia, Università di Perugia.
Farmaco (Societa Chimica Italiana : 1989)
|January 1, 1993
Abstract:
We have prepared twelve imidazo[2,1-b]benzothiazole carboxylic and acetic acids by reaction of substituted 2-aminobenzothiazoles with ethyl bromopyruvate and 4-chloroacetoacetate, respectively. The acids, obtained from esters by hydrolysis, were tested for their antiinflammatory, analgesic and ulcerogenic activities.