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Related Experiment Videos

Application of gluconolactone in direct tablet compression

S S Nasir, L O Wilken, B Akhtar

    Journal of Pharmaceutical Sciences
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Gluconolactone shows promise as a direct compression excipient, yielding high-quality tablets with good physical properties. It also demonstrated minimal drug degradation and no impact on bioavailability in preliminary studies.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Direct compression is a preferred method for tablet manufacturing.
    • Identifying suitable excipients is crucial for successful direct compression tablet formulation.

    Purpose of the Study:

    • To evaluate gluconolactone as a novel excipient for direct compression.
    • To compare gluconolactone with common diluents like anhydrous lactose.

    Main Methods:

    • Tablets were prepared by direct compression using gluconolactone and various drugs.
    • Physical properties were assessed post-compression and after storage.
    • Comparative studies included static charge, flow, drug distribution, compressibility, and mold resistance.
    • Drug stability and in vivo bioavailability were evaluated.

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    Main Results:

    • Tablets formulated with gluconolactone exhibited satisfactory physical properties.
    • Gluconolactone demonstrated superior performance compared to anhydrous lactose in several aspects.
    • Gluconolactone showed the least drug degradation and did not affect aspirin absorption in vivo.

    Conclusions:

    • Gluconolactone is a viable excipient for direct compression tablet manufacturing.
    • It offers advantages in terms of tablet quality, drug stability, and bioavailability.
    • Further research into gluconolactone as a pharmaceutical excipient is warranted.