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Calcific phacolysis

M W Scroggs1, A D Proia, N C Charles

  • 1Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710.

Ophthalmology
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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This study describes calcific phacolysis, a rare condition where calcified lens particles disperse within the eye years after trauma causing blindness. This leads to inflammation and elevated intraocular pressure.

Area of Science:

  • Ophthalmology
  • Pathology

Background:

  • Reports clinical and histopathologic findings in three patients with longstanding unilateral post-traumatic blindness.
  • Describes delayed onset of pain, conjunctival hyperemia, and anterior chamber inflammation (keratoprecipitates or hypopyon) decades after initial trauma.

Observation:

  • Histopathology revealed dispersed calcified granular lens fragments within all three affected eyes.
  • Extracellular calcified lens particles were present in the anterior chamber, with macrophages noted in only one eye.
  • Two eyes exhibited elevated intraocular pressure (IOP), with one case showing calcified particles extending into the optic nerve head.

Findings:

  • Identifies intraocular dispersal of calcified lens particles following lens capsule disruption.
  • Documents a rare condition, termed calcific phacolysis, presenting years after traumatic lens injury.

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Implications:

  • Highlights a previously undescribed cause of delayed ocular inflammation and secondary glaucoma after trauma.
  • Suggests the importance of considering calcific phacolysis in patients with a history of ocular trauma presenting with unexplained ocular inflammation and pain.