Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatotoxicity in acetaminophen poisoning

D R Ferguson, S K Synder, A J Cameron

    Mayo Clinic Proceedings
    |April 1, 1977
    PubMed
    Summary

    Acetaminophen overdose can cause severe liver damage, indicated by elevated SGOT and prolonged prothrombin time. Fortunately, this young woman experienced a complete spontaneous recovery from her liver injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A disease-associated gene desert directs macrophage inflammation through ETS2.

    Nature·2024
    Same author

    A synthetic approach to 'click' neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry.

    Chemical science·2019
    Same author

    Socioeconomic inequalities in weight, height and body mass index from birth to 5 years.

    International journal of obesity (2005)·2018
    Same author

    Targeting protein kinase C in sarcoma.

    Biochimica et biophysica acta·2014
    Same author

    Effect of changes to the school food environment on eating behaviours and/or body weight in children: a systematic review.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2014
    Same author

    Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice.

    Genes, brain, and behavior·2013

    Area of Science:

    • Hepatology
    • Toxicology
    • Internal Medicine

    Background:

    • Acetaminophen (paracetamol) is a common over-the-counter analgesic and antipyretic.
    • Intentional overdose can lead to severe, potentially fatal, hepatotoxicity.
    • Understanding the clinical and biochemical profile of acetaminophen toxicity is crucial for patient management.

    Observation:

    • A young woman presented after an acetaminophen overdose with symptoms of severe liver damage.
    • Clinical signs included persistent nausea, vomiting, and hepatic pain and tenderness.
    • Biochemical markers indicated significant hepatocellular injury.

    Findings:

    • Serum glutamic-oxaloacetic transaminase (SGOT) levels exceeded 3,000 units/L.
    • Prothrombin time was significantly prolonged, suggesting impaired hepatic synthetic function.
    • Alkaline phosphatase and serum bilirubin levels remained within normal or near-normal ranges, respectively.

    Implications:

    • This case highlights the potential for severe liver damage from acetaminophen overdose.
    • Prompt recognition of clinical and biochemical indicators is vital for timely intervention.
    • The case demonstrates that complete spontaneous recovery is possible even after significant acetaminophen-induced hepatotoxicity.

    Related Experiment Videos