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Published on: November 4, 2010
Characteristics and mechanisms of nocturnal asthma
1University of Colorado Health Sciences Center, National Jewish Center for Immunology and Respiratory Medicine, Denver.
Abstract:
Nocturnal worsening of asthma is a very common and significant problem for the vast majority of all asthmatic patients. The involved mechanisms are multiple and interactive. These include circadian alterations in inflammation/mediators, epinephrine, beta 2 receptor function, vagal tone, and body temperature. Other factors may include aspiration, sinusitis, and sleep apnea. Understanding of the mechanisms involved in nocturnal asthma directs the therapeutic approach of these patients.
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