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Immune responses in male mice with aggressive and submissive behavior patterns: strain differences
L Devoino1, E Alperina, N Kudryavtseva
1Institute of Physiology Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk.
Brain, Behavior, and Immunity
|March 1, 1993
Summary
Aggressive CBA male mice showed increased immune cells after confrontations, while aggressive C57BL males did not. Submissive C57BL mice exhibited decreased immune cell counts following social stress.
Area of Science:
- Immunology
- Behavioral Science
- Animal Models
Background:
- Social behavior and dominance hierarchies can influence physiological responses.
- Understanding the link between aggression, submission, and immune function is crucial.
Purpose of the Study:
- To investigate how aggressive and submissive behaviors impact immune responses in different mouse strains.
- To compare immune cell dynamics in aggressive versus submissive male mice.
Main Methods:
- Two mouse strains (CBA and C57BL) were categorized by aggressive and submissive behavior.
- Immune responses were assessed by measuring plaque-forming cells (PFC) and rosette-forming cells (RFC).
- Mice were subjected to agonistic confrontations.
Main Results:
- Aggressive CBA males showed increased PFC and RFC counts post-confrontation compared to controls.
- Aggressive C57BL males exhibited no significant change in PFC and RFC levels.
- Submissive C57BL males displayed a decrease in both PFC and RFC numbers.
Conclusions:
- Strain-dependent differences exist in immune responses to social confrontation.
- Aggression in CBA mice correlates with enhanced immune activity, while submission in C57BL mice is linked to immune suppression.