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Diffuse chondrolytic arthritis in sickle cell disease

H R Schumacher1, D Van Linthoudt, C S Manno

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.

The Journal of Rheumatology
|February 1, 1993
PubMed
Summary

Sickle cell disease can cause rapid joint destruction. Phagocytic cells in the synovium may play a key role in this process, leading to severe arthritis and the need for hip replacement.

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Area of Science:

  • Rheumatology
  • Hematology
  • Pathology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin.
  • Vaso-occlusive crises are a hallmark of SCD, causing severe pain and organ damage.
  • Polyarticular chondrolysis is a rare but devastating complication affecting joints.