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The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
1Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406.
Molecular & General Genetics : MGG
|April 1, 1993
Abstract:
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.