Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective modification and immune evasion: a hypothesis

S Kumar1

  • 1Department of Biology, Imperial College of Science, Technology and Medicine, London, UK.

Immunology and Cell Biology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic relevance of serum hyaluronan levels in patients with breast cancer.

International journal of cancer·1992
Same author

Acceptability trials with ready to eat foods in a rural area.

Indian pediatrics·1992
Same author

American Diabetes Association annual scientific sessions, San Antonio, 20-23 June 1992.

Diabetic medicine : a journal of the British Diabetic Association·1992
Same author

Localization of the gene for branchiootorenal syndrome to chromosome 8q.

Genomics·1992
Same author

Expression of DRG during murine embryonic development.

Biochemical and biophysical research communications·1992
Same author

DRG: a novel developmentally regulated GTP-binding protein.

Biochemical and biophysical research communications·1992
Same journal

Multi-Omics Comes of Age: Immune Profiling of Human Aging.

Immunology and cell biology·2026
Same journal

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.

Immunology and cell biology·2026
Same journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same journal

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach.

Immunology and cell biology·2026
Same journal

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.

Immunology and cell biology·2026
Same journal

Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.

Immunology and cell biology·2026
See all related articles

Parasites evade host defenses by evolving enzyme active sites that mimic host enzymes. This molecular mimicry allows parasites to avoid immune detection, even when their enzymes are immunogenic.

Area of Science:

  • Parasitology
  • Immunology
  • Biochemistry
  • Molecular Biology

Background:

  • Host immune responses often target parasite-derived enzymes.
  • Enzyme neutralization is typically an effective defense mechanism against pathogens.
  • Despite this, enzyme neutralization is not a potent host response against many parasites.

Purpose of the Study:

  • To hypothesize why enzyme neutralization is ineffective against parasites.
  • To explore the evolutionary mechanisms parasites employ to evade host immunity.

Main Methods:

  • Hypothetical model proposing evolutionary convergence of parasite enzyme active sites.
  • Analysis of structural and functional similarities between parasite and host enzyme active sites.

Related Experiment Videos

  • Consideration of molecular mimicry as an immune evasion strategy.

    • Main Results:

    • Parasite enzyme structural domains can be immunogenic.
    • Active sites of parasite enzymes may evolve to resemble host enzyme active sites.
    • This convergence facilitates functional adaptation and immune evasion.

    Conclusions:

    • Evolutionary convergence of enzyme active sites is a key parasite immune evasion strategy.
    • Molecular mimicry of host enzymes allows parasites to avoid immune detection.
    • Parasites can tolerate antiparasite enzyme antibodies without suffering detrimental effects.