Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A high-resolution XRII-based quantitative volume CT scanner

D W Holdsworth1, M Drangova, A Fenster

  • 1Imaging Research Laboratories, John P. Robarts Research Institute, London, Ontario, Canada.

Medical Physics
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reliability and concurrent validity of three-dimensional ultrasound for quantifying knee cartilage volume.

Osteoarthritis and cartilage open·2022
Same author

High tibial osteotomy to neutral alignment improves medial knee articular cartilage composition.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2021
Same author

Extending the dynamic range of biomedical micro-computed tomography for application to geomaterials.

Journal of X-ray science and technology·2019
Same author

Rigid-body motion correction in hybrid PET/MRI using spherical navigator echoes.

Physics in medicine and biology·2019
Same author

Morphology-Specific Discrimination between MS White Matter Lesions and Benign White Matter Hyperintensities Using Ultra-High-Field MRI.

AJNR. American journal of neuroradiology·2018
Same author

SU-E-T-273: Commissioning Motorized Jaws for a Micro-CT/RT.

Medical physics·2017
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

A new laboratory computed tomography (CT) scanner offers high-resolution 3D imaging for in vitro tissue analysis. This non-destructive technique provides precise quantitative and geometric measurements for biomedical research applications.

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Radiology

Background:

  • Quantitative analysis of excised tissue samples is crucial for biomedical research.
  • Existing imaging techniques may lack the necessary spatial resolution or quantitative accuracy.
  • Development of advanced imaging systems is needed for detailed in vitro studies.

Purpose of the Study:

  • To develop and characterize a laboratory volume CT scanner for high-resolution, quantitative in vitro analysis of excised tissue samples.
  • To evaluate the system's performance in terms of spatial resolution, linearity, and precision.
  • To discuss potential applications in biomedical research.

Main Methods:

  • A laboratory volume CT scanner was developed using an x-ray image intensifier coupled to a time-delay integration (TDI) CCD.

Related Experiment Videos

  • A water bath was employed to equalize sample exposure and reduce signal dynamic range.
  • The system was operated in two modes: single transverse imaging and 3D volume imaging.

    • Main Results:

    • The scanner achieves high spatial resolution adjustable from 1.2 to 2.8 mm-1.
    • System response linearity was confirmed over -1000 to 3500 Hounsfield units (HU), with an average precision of +/- 80 HU.
    • Geometric measurements in the transverse plane demonstrated high precision, allowing circumference measurements within +/- 0.1 mm.

    Conclusions:

    • The developed laboratory volume CT scanner provides high-resolution, quantitative, and non-destructive analysis of excised tissues in vitro.
    • The system's precision and adjustable resolution make it a valuable tool for biomedical research.
    • This technology enables detailed characterization of tissue samples, supporting advancements in various research fields.