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[Hypotensive effect of dihydrolycorine]
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|January 1, 1993
Summary
Dihydrolycorine-HCL, a lycorine derivative, effectively lowers blood pressure in various animal models by blocking alpha 1-adrenoceptors. This compound shows potential for cardiovascular research.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
- Natural Products Chemistry
Context:
- Lycorine alkaloids, derived from Lycoris radiata, are known for diverse biological activities.
- Understanding the cardiovascular effects of novel alkaloid derivatives is crucial for drug discovery.
Purpose:
- To investigate the hypotensive effects and mechanism of action of Dihydrolycorine-HCL (DL).
Summary:
- Dihydrolycorine-HCL (DL) administered intravenously reduced mean arterial pressure in normotensive and hypertensive rats and cats.
- DL inhibited pressor responses to spinal cord stimulation and phenylephrine in pithed rats.
- DL antagonized methoxamine-induced contractions in isolated rabbit aorta and rat anococcygeus muscle, indicating alpha 1-adrenoceptor blockade.
Impact:
- These findings suggest that Dihydrolycorine-HCL acts as an alpha 1-adrenoceptor antagonist.
- DL represents a potential therapeutic agent or research tool for conditions involving alpha 1-adrenergic signaling.