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Excel: a new cell separator in its very first clinical application
M Valbonesi1, R Frisoni, G Giannini
1Centro Trasfusionale, Ospedale San Martino, Genova, Italia.
Infusionstherapie Und Transfusionsmedizin
|April 1, 1993
Summary
Preliminary results show the Excel cell separator effectively performs thrombocytapheresis, yielding high-quality platelet products with minimal contamination. This advanced technology demonstrates satisfactory platelet yield and efficiency in early trials.
Area of Science:
- Medical Technology
- Hematology
- Apheresis
Background:
- Technological advancements have significantly impacted thrombocytapheresis procedures over time.
- This study presents initial findings on the Excel, a third-generation cell separator in its experimental phase.
Purpose of the Study:
- To evaluate the preliminary performance of the Excel cell separator in thrombocytapheresis.
- To assess platelet yield, contamination levels, and product quality.
Main Methods:
- Conducted 15 thrombocytapheresis procedures on healthy donors, processing 4 liters of blood.
- Included 2 procedures using a single-needle technique.
Main Results:
- Achieved an average platelet yield of 4.7 x 10(11) with low leukocyte (0.8 x 10(6)) and RBC (0.4 x 10(7)) contamination.
- Demonstrated a platelet efficiency of 6.5 x 10(9) per minute with an average run time of 72 minutes.
- Platelet aggregation studies showed good response to ADP, collagen, and ristocetin, with minimal aggregates in the final product (Wu-Hoak ratio: 0.91).
Conclusions:
- The Excel cell separator produced satisfactory platelet yields and quality in preliminary thrombocytapheresis procedures.
- The device shows promise for efficient and effective platelet collection with minimal contamination.