Human uterine protein in relation to infertility

The concentration of electrophoretic protein in the uterine fluid of infertile women is significantly higher at all the phases of the menstrual cycle, except at phase I where it is significantly (p < 0.01) lower than parous women. At phase III (ovulatory phase) the concentration of electrophoretic protein (2812.00 micrograms/ml) is maximum in infertiles, and shows a highly significant (p < 0.001) increase over that of parous women (954.85 micrograms/ml). The highest level of electrophoretic protein at phase III in infertile women is due to maximum increase in anodic (electronegative) protein at this stage. This suggests that significant (p < 0.001) increase in concentration of anodic protein in the uterine fluid of infertile women at the ovulatory phase adds negative charge on sperm membrane that may possibly affect the capacitation of spermatozoa, thus causing infertility in women.