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[Sequential estrogen and radiation therapy for stage C prostate cancer]
Y Tachibana1, T Kawai, T Kobayashi
1Department of Urology, Cancer Institute Hospital.
Summary
Sequential estrogen and radiation therapy showed a 94.4% improvement rate for stage C prostate cancer. This combined treatment offers a promising option for localized prostate cancer, with an 81% five-year non-recurrence rate.
Area of Science:
- Oncology
- Radiation Oncology
- Endocrinology
Context:
- Stage C prostate cancer treatment historically involves various modalities.
- Sequential estrogen and radiation therapy was explored to enhance outcomes.
- Staging operations were utilized to refine patient selection.
Purpose:
- To evaluate the efficacy of sequential estrogen and radiation therapy for stage C prostate cancer.
- To assess treatment response, recurrence rates, and long-term outcomes.
Summary:
- 34 stage C prostate cancer patients were treated between 1980-1989, with 20 receiving sequential estrogen and radiation therapy.
- The treatment involved 70 Gy radiation over seven weeks, with continuous estrogen administration in 11 cases.
- Therapeutic effects showed a 94.4% improvement rate and 50% atrophy rate; 81% had a five-year non-recurrence rate.
Impact:
- Sequential estrogen and radiation therapy demonstrated significant local control and a high improvement rate in stage C prostate cancer.
- The study highlights the potential of combined modality treatment for localized prostate cancer.
- Findings contribute to understanding long-term efficacy and recurrence patterns in this patient cohort.