Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neoadjuvant therapy for prostatic cancer]

O Maeda1, S Saiki, T Kinouchi

  • 1Department of Urology, Center for Adult Diseases, Osaka.

Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The results of radiotherapy for T1 glottic cancers; influence of radiation beam energy.

Acta medica Okayama·1999
Same author

For the clinical application of thermochemotherapy given at mild temperatures.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·1999
Same author

Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912.

Microbiology and immunology·1999
Same author

Influence of metabolic inhibitors on the intracellular accumulation and retention of adriamycin.

Anticancer research·1999
Same author

Induction of a secreted protein by the myxoid liposarcoma oncogene.

Proceedings of the National Academy of Sciences of the United States of America·1999
Same author

[Renal oncocytoma with cystic degeneration: a case report].

Hinyokika kiyo. Acta urologica Japonica·1999
Same journal

[CASE OF EPIDIDYMITIS LEADING TO DIAGNOSIS OF INCOMPLETE BEHCET'S DISEASE].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
Same journal

[A CASE OF INGUINAL HERNIA MESH MIGRATION INTO THE BLADDER].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
Same journal

[A CASE OF PENILE VERRUCOUS CARCINOMA: DIAGNOSTIC DIFFICULTIES WITH BIOPSY].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
Same journal

[MUSCLES MAY MOVE NOT ONLY TO THE LONGITUDINAL DIRECTION BUT ALSO TO THE LATERAL DIRECTION ----- A NEW PRINCIPLE DEVELOPED FROM THE OPENING ACTIVITY OF THE URETHRA ----].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
Same journal

[A CASE OF ACUTE EXACERBATION OF INTERSTITIAL PNEUMONIA AFTER ROBOT-ASSISTED TOTAL CYSTECTOMY].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
Same journal

[ENTERIC ADENOCARCINOMA DIAGNOSED VIA IMMUNOHISTOCHEMISTRY AND GENOME TESTING OF A PORT SITE MASS AFTER ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY: A CASE REPORT].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·2026
See all related articles

Neoadjuvant therapy before prostatectomy improves outcomes for advanced prostate cancer. Longer treatment durations correlate with better clinical and pathological responses, suggesting its vital role in enhancing cure rates.

Area of Science:

  • Oncology
  • Urology
  • Surgical Oncology

Context:

  • Prostate cancer management often involves multimodal approaches.
  • Neoadjuvant therapy aims to improve surgical outcomes and organ preservation.
  • Evaluating the efficacy of neoadjuvant therapy in a historical cohort is crucial.

Purpose:

  • To assess the impact of neoadjuvant therapy on clinical and histopathological outcomes in patients undergoing prostatectomy.
  • To determine the correlation between neoadjuvant therapy duration and treatment response.
  • To identify factors influencing downstaging and overall treatment effectiveness.

Summary:

  • A retrospective study analyzed 43 prostate cancer cases treated with neoadjuvant therapy followed by radical prostatectomy (1975-1990).

Related Experiment Videos

  • Clinical response rates (PR/MR/NC) and histopathological effects (Grades 0a-3) were evaluated.
  • Duration of neoadjuvant therapy, clinical response, and histopathological effects, including downstaging, were key outcome measures.

    • Impact:

    • Neoadjuvant therapy demonstrated a role in advanced prostate cancer, with longer durations yielding better clinicopathological effects.
    • Significant histopathological improvements, including apparent resolution of lymph node metastases in two cases, were observed.
    • The findings support neoadjuvant therapy as an important component in the treatment of advanced prostate cancer, potentially increasing cure rates and organ preservation.