Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetic inheritance in mammals

M F Lyon1

  • 1MRC Radiobiology Unit, Didcot, Oxon, UK.

Trends in Genetics : TIG
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Mammalian genome imprinting and X-chromosome inactivation involve differential gene/chromosome behavior within cells. Imprinting focuses on single genes, while X-inactivation coordinates entire chromosomes for genic balance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charles Edmund Ford.

Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain)·2004
Same author

X-chromosome inactivation and human genetic disease.

Acta paediatrica (Oslo, Norway : 1992). Supplement·2003
Same author

A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35.

Genomics·2001
Same author

Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop).

Molecular vision·2000
Same author

An answer to a complex problem: cloning the mouse t-complex responder.

Mammalian genome : official journal of the International Mammalian Genome Society·2000
Same author

LINE-1 elements and X chromosome inactivation: a function for "junk" DNA?

Proceedings of the National Academy of Sciences of the United States of America·2000
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Area of Science:

  • Epigenetics
  • Genomics
  • Mammalian Biology

Background:

  • Genome imprinting and X-chromosome inactivation are key epigenetic processes in mammals.
  • Both phenomena involve differential behavior of homologous genetic elements within the same cell.
  • They impact the overall genic balance of the genome.

Purpose of the Study:

  • To compare and contrast the regulatory mechanisms of genome imprinting and X-chromosome inactivation.
  • To highlight the differences in their control levels and scope within the cell.

Main Methods:

  • Comparative analysis of epigenetic regulatory mechanisms.
  • Review of existing literature on imprinting and X-chromosome inactivation.
  • Examination of gene and chromosome-level regulation in mammals.

Related Experiment Videos

Main Results:

  • Genome imprinting primarily involves regulation at the single gene level.
  • X-chromosome inactivation demonstrates coordinated regulation across an entire chromosome.
  • Single gene effects are less significant in X-chromosome inactivation compared to imprinting.

Conclusions:

  • Distinct regulatory strategies exist for genome imprinting and X-chromosome inactivation.
  • Understanding these differences is crucial for comprehending mammalian epigenetic control.
  • The scale of regulation (single gene vs. whole chromosome) differentiates these two epigenetic phenomena.