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Gene expression during metamorphosis: an ideal model for post-embryonic development

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  • 1Laboratory of Developmental Biochemistry, National Institute for Medical Research, London, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Insect and amphibian metamorphosis, induced by hormones like ecdysteroids, provides insights into post-embryonic development. Hormone receptor gene auto-induction models explain adult gene activation during this crucial developmental process.

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Area of Science:

  • Developmental Biology
  • Endocrinology
  • Comparative Physiology

Background:

  • Hormonal regulation of metamorphosis in insects and amphibians involves ecdysteroids and thyroid hormones.
  • Key hormones like juvenile hormone and prolactin can inhibit or retard metamorphic processes.
  • Metamorphosis shares developmental parallels with late fetal and perinatal mammalian development.

Purpose of the Study:

  • To review the regulation of 'adult' gene product expression during invertebrate and vertebrate metamorphosis.
  • To present a model for 'downstream' gene activation based on hormone receptor gene auto-induction.
  • To highlight metamorphosis as a model system for studying post-embryonic development.

Main Methods:

  • Analysis of exogenous hormone-induced metamorphosis in vivo and in culture.
  • Review of gene expression regulation during metamorphosis.
  • Development of a model for gene activation via hormone receptor auto-induction.

Main Results:

  • Identified key roles of ecdysteroids, thyroid hormones, juvenile hormone, and prolactin in regulating metamorphosis.
  • Demonstrated the significance of auto-induction of hormone receptor genes.
  • Proposed a model explaining the activation of genes leading to the adult phenotype.

Conclusions:

  • Metamorphosis is a crucial process for analyzing diverse post-embryonic developmental events.
  • Hormone receptor gene auto-induction is central to activating adult phenotype genes.
  • Metamorphosis serves as an excellent model for understanding general mechanisms of post-embryonic development.