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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Published on: September 27, 2018
[Descriptive study of 39 cases of hepatic abscess of pyogenic and amebic origin]
F Blanco Quintana1, B Novella Arribas, P Sánchez Molini
1Servicio de Medicina Interna-Infecciosas, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid.
Abstract:
Thirty nine cases of liver abscess--33 pyogenic (LAP) and 6 amebic (LAA)--attended in our hospital between 1980 and 1994, were reviewed. Mean patient age was 55.66 years (LAP) and 35.83 years (LAA), while the relation male/female was 2.3:1 and 5:1 respectively. The most usual underlying pathology in LAP was bile duct disease (39.39%). Four patients with LAA had travelled to endemic areas. Fever was the most frequent clinical finding (71.79%). Echography and/or CT scan confirmed the diagnosis in 32 patients (82.05%), with a sensitivity of 86.66 and 95.65% respectively. Positive cultures were found in 74.35% (39.13% polymicrobials), being E. Coli and K. Pneumoniae the most frequently isolated bacteria. In LAP pus cultures were positive in 73% and blood cultures in 55%. Diagnosis of LAA was made by wet mount smears/serology (3/3). Percutaneous drainage was performed in 41.02%, surgical drainage in 48.71 and 15.38% (all with LAP) received antibiotics exclusively. Four patients died (3 with LAP and 1 with LAA).
Insights
This review of liver abscess cases found pyogenic liver abscesses more common than amebic ones, with bile duct disease a frequent cause. Imaging like CT scans proved highly effective for diagnosis.
Area of Science:
- Hepatology
- Infectious Diseases
- Radiology
Context:
- A retrospective review of 39 liver abscess cases (33 pyogenic, 6 amebic) treated between 1980 and 1994.
- Analysis of patient demographics, underlying pathologies, clinical presentations, diagnostic methods, and treatment outcomes.
Purpose:
- To review and analyze the characteristics and management of pyogenic and amebic liver abscesses.
- To evaluate the diagnostic accuracy of imaging modalities and microbiological cultures.
Summary:
- Pyogenic liver abscesses (PLA) were more prevalent, with a mean age of 55.66 years and a male-to-female ratio of 2.3:1. Bile duct disease was the most common underlying pathology.
- Amebic liver abscesses (ALA) occurred in younger patients (mean age 35.83 years, M:F ratio 5:1), with travel to endemic areas noted in some cases.
- Fever was the most common symptom. Echography and CT scans demonstrated high diagnostic sensitivity (86.66% and 95.65%, respectively). Escherichia coli and Klebsiella pneumoniae were the most frequent bacterial isolates in PLA.
- Drainage procedures (percutaneous or surgical) were common interventions. The overall mortality rate was 10.26% (4/39 patients).
Impact:
- Highlights the importance of imaging techniques like CT scans in diagnosing liver abscesses.
- Provides insights into the common pathogens and predisposing factors for pyogenic liver abscesses.
- Contributes to understanding the clinical presentation and management strategies for both pyogenic and amebic liver abscesses.
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