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Finger-like lysing patterns of blood clots
A Zidansek1, A Blinc, G Lahajnar
1J. Stefan Institute, University of Ljubljana, Slovenia.
Biophysical Journal
|September 1, 1995
Summary
This study explains blood clot dissolution patterns using a two-dimensional model. The fractal dimension of these patterns changes during clot recanalization, offering insights into fibrinolysis.
Area of Science:
- Biophysics
- Biomedical Engineering
- Chemical Engineering
Background:
- One-dimensional models of fibrinolysis explain dissolution velocity but not pattern shape.
- Two- and three-dimensional models are needed to accurately describe drug-induced blood clot dissolution patterns.
Purpose of the Study:
- To explain the fractal shape of blood clot lysis patterns.
- To model drug-induced blood clot dissolution using a two-dimensional approach.
Main Methods:
- Utilized proton nuclear magnetic resonance imaging to obtain blood clot dissolution patterns.
- Employed a two-dimensional calculation based on Hele-Shaw random walk models.
- Incorporated enzyme transport-limited fibrinolytic equations with diffusion and perfusion terms, considering gel porosity.
Main Results:
- Two-dimensional modeling successfully explained the fractal nature of observed lysing patterns.
- The fractal dimension of experimental patterns varied from 1.2 initially to a maximum of approximately 1.3, then decreased to one during recanalization.
Conclusions:
- Two-dimensional modeling, accounting for gel porosity, accurately describes fractal fibrinolysis patterns.
- The dynamic change in fractal dimension provides a quantitative measure of clot recanalization during fibrinolysis.