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Published on: August 28, 2013
A potential single insertion protocol for quinacrine pellet non-surgical female sterilization
B C Mullick1, E Kessel, S D Mumford
1Indian Rural Medical Association, Calcutta, India.
Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|September 1, 1995
Summary
The quinacrine pellet method for non-surgical female sterilization showed improved efficacy when combined with medroxyprogesterone acetate. This combination significantly reduced pregnancy failure rates compared to oral contraceptives in preliminary trials.
Area of Science:
- Reproductive Medicine
- Gynecology
- Contraception
Background:
- Non-surgical female sterilization methods are sought for reversible contraception.
- Quinacrine pellets offer a potential non-surgical approach.
- Previous trials require optimization for improved efficacy.
Purpose of the Study:
- To compare the efficacy of the quinacrine pellet method with and without medroxyprogesterone acetate.
- To evaluate pregnancy failure rates in two distinct clinical trials.
Main Methods:
- Two preliminary single-insertion clinical trials were conducted.
- Quinacrine (252 mg) and diclofenac (75 mg) pellets were applied transcervically.
- Trial 1: 58 women received oral contraceptives for 3 months.
- Trial 2: 229 women received medroxyprogesterone acetate (150 mg IM) at insertion.
Main Results:
- At 18 months, the pregnancy failure rate was 8.6% (SE 3.7) in the oral contraceptive group.
- The medroxyprogesterone acetate group had a significantly lower failure rate of 0.5% (SE 0.5), p<0.05.
- No serious complications or side-effects were reported in either group.
Conclusions:
- Medroxyprogesterone acetate appears to enhance the efficacy of the quinacrine pellet method for female sterilization.
- Larger randomized trials with long-term follow-up are necessary to confirm these findings.
