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100,000 quinacrine sterilizations

E Kessel1

  • 1Department of Public Health and Preventive Medicine, Oregon Health Sciences University, Portland 97201, USA.

Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|June 1, 1996
PubMed
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Quinacrine nonsurgical female sterilization offers a safe and effective permanent family planning method. This procedure has shown high efficacy and minimal side effects, making it a valuable option for women globally.

Area of Science:

  • Reproductive Health
  • Medical Devices
  • Public Health

Background:

  • Nonsurgical female sterilization using quinacrine has been performed over the past decade.
  • This method involves transcervical insertion of quinacrine pellets.
  • It is administered through one, two, or three monthly insertions.

Purpose of the Study:

  • To evaluate the safety and efficacy of quinacrine nonsurgical female sterilization.
  • To assess the long-term outcomes and potential risks associated with the procedure.
  • To highlight the benefits of quinacrine sterilization in increasing contraceptive prevalence.

Main Methods:

  • Transcervical insertion of quinacrine (252 mg) as pellets.
  • The procedure was administered in one, two, or three monthly sessions.

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  • Efficacy was tracked by monitoring pregnancy failures per 100 women annually.

    • Main Results:

    • Over 100,000 procedures completed with no reported deaths.
    • Serious complications are significantly lower compared to surgical sterilization.
    • Efficacy improved to approximately 1 pregnancy failure per 100 women.
    • Long-term follow-up shows no increased cancer risk.
    • Mild and transient side effects were observed.

    Conclusions:

    • Quinacrine sterilization is an economical and safe permanent family planning method.
    • It effectively reduces maternal mortality and morbidity, particularly in developing countries.
    • The method should be accessible to well-informed women worldwide.