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Haemophilus aphrophilus discitis and vertebral osteomyelitis
J C O'Driscoll1, G S Keene, M J Weinbren
1Department of Microbiology, RTR Healthcare NHS Trust, Queen Mary's University Hospital, Roehampton, London, UK.
Scandinavian Journal of Infectious Diseases
|January 1, 1995
Summary
A rare case of discitis and vertebral osteomyelitis caused by Haemophilus aphrophilus, an organism typically treated with beta-lactam antibiotics, was observed. This specific bacterial isolate showed resistance to third-generation cephalosporins, a previously unreported finding, and was successfully treated with ciprofloxacin.
Area of Science:
- Infectious Diseases
- Microbiology
- Orthopedics
Background:
- Discitis and vertebral osteomyelitis are serious spinal infections.
- Haemophilus aphrophilus is a rare cause of these conditions.
- Beta-lactam antibiotics are the standard treatment for H. aphrophilus infections.
Observation:
- An unusual case of discitis and vertebral osteomyelitis was diagnosed.
- The causative agent was identified as Haemophilus aphrophilus.
- The patient's isolate exhibited resistance to third-generation cephalosporins, a novel observation.
Findings:
- The Haemophilus aphrophilus isolate demonstrated resistance to third-generation cephalosporins.
- This resistance pattern has not been previously documented in global literature.
- The patient achieved a positive clinical outcome with ciprofloxacin therapy.
Implications:
- Highlights the emergence of antibiotic resistance in H. aphrophilus.
- Suggests ciprofloxacin as a potential alternative treatment for resistant cases.
- Underscores the need for susceptibility testing in spinal infections.